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Proceeds from the song's sales on iTunes were donated to the Global Fund to Fight AIDS, Tuberculosis and Malaria .

The campaign aimed to engage millennials to help end mother-to-child transmission of HIV.

The core theme of the song is the transformation of tragedy into triumph. Wyclef explained that the "whole idea with the song is, it's a celebration song. No matter what you're going through today, you're going to overcome it tomorrow". He was specifically inspired by a visit to a clinic in Africa where he met an HIV-positive mother whose baby was born negative—a moment she described as turning her "saddest moment" into her "most joyous". Visual Identity

Musically, the song is categorized as . It begins with Wyclef’s emotional, digitally treated vocals before building into a "crescendo of synthesizers" and a pulsing beat characteristic of Avicii’s signature style.

The song was accompanied by two distinct lyric videos that emphasized its message:

Transforming Pain into Hope: The Story Behind "Divine Sorrow"

Watch the official lyric video that supported the (RED) campaign's mission to fight AIDS: Wyclef feat. Avicii Divine Sorrow | Lyric Video Wyclef Jean YouTube• Jul 10, 2015

Released in July 2015, it featured Wyclef and Greek artist INO painting the song's lyrics on a wall alongside local children.