The binding requires cooperation between multiple C2 domains to secure the vesicle to the target membrane.
This molecular mechanism allows the ear to convert sound into neural signals at incredibly high speeds. tm,cc,jp
Binding Sites: High-resolution structures revealed that multiple Ca 2+raised to the 2 plus power The binding requires cooperation between multiple C2 domains
The protein utilizes several C2 domains (C2A-C2F) to bind Ca 2+raised to the 2 plus power and lipids, as shown in the protein structure below. 2. C2 Domains: Function & Interactions a "closed" conformation is adopted
Upon binding, a "closed" conformation is adopted, where C-terminal domains (C2F, C2G) rearrange. 3. Key Findings in Synaptic Transmission Ca 2+raised to the 2 plus power
Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding.