In patients with idiopathic pulmonary arterial hypertension, a higher plasma MMP2/TIMP4 ratio is used as a predictor of disease severity and worsened survival. 3. Role in Pregnancy and Tissue Remodeling
Mice lacking the TIMP4 gene showed increased inflammation, indicating its anti-inflammatory role in diseases. Titlimp4
Tissue inhibitor of metalloproteinases 4 (TIMP4) belongs to a crucial family of proteins designed to keep the body’s extracellular matrix (ECM) in balance. It acts as an inhibitor of matrix metalloproteinases (MMPs), which are enzymes that break down connective tissue. and 3 are expressed widely
While TIMP1, 2, and 3 are expressed widely, TIMP4 is expressed in a more tissue-specific manner. It acts as the major intraplatelet MMP inhibitor, playing a key role in regulating platelet aggregation. Conclusion: Future Therapeutic Potential Titlimp4