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In this episode, Sam and Dean Winchester continue to deal with the immediate aftermath of releasing (Amara). The story splits between Sam's desperate attempt to find a cure for a mysterious "rabies-like" infection and Dean's encounter with the young Amara. Summary of Key Events

The title is a biblical reference to , which describes the earth before creation as "without form and void" ( tohut o h u bohub o h u

Dean discovers a birthmark on the baby Amara that is identical to the Mark of Cain, confirming her identity as The Darkness.

Crowley arrives, sensing the immense power within Amara, and attempts to take her under his wing, seeing her as a potential ultimate weapon. Why "Form and Void"?