Nucleoside Reverse Transcriptase Inhibitor < LEGIT - TIPS >

Nucleoside Reverse Transcriptase Inhibitors (NRTIs) are a foundational class of antiretroviral drugs used primarily in the treatment of HIV-1 infection. Often referred to as "nukes," these agents structurally mimic naturally occurring nucleosides (the building blocks of DNA) to interfere with the viral replication cycle.

Clinically approved NRTIs are frequently used in combination therapies to improve efficacy and reduce the risk of drug resistance. Notable examples include: nucleoside reverse transcriptase inhibitor

Because NRTIs lack a 3'-hydroxyl group, once they are incorporated into the growing viral DNA strand, no further nucleotides can be added. This prematurely stops the conversion of viral RNA into DNA, preventing the virus from replicating. Commonly Used NRTIs nucleoside reverse transcriptase inhibitor