The dynamic of this rivalry shifted significantly during the 2024 season, which saw Arizona complete a rare sweep of San Francisco.
The and San Francisco 49ers have a storied NFC West rivalry, with the 49ers currently leading the all-time series 38–31 . Recent Series Recap (2024–2025 Seasons) NFL San Francisco 49ers vs Arizona Cardinals
The Cardinals overcame a halftime deficit to stun the 49ers 24–23 at Levi's Stadium. This game set a record for the hottest regular-season kickoff at the stadium at The dynamic of this rivalry shifted significantly during