G9048.mp4

: Injured epithelial cells release Sonic Hedgehog (SHH) ligands.

The research, published in journals such as and archived on PMC , explores how tissue stiffness and biochemical signaling work together to drive cancer growth. Key Research Findings g9048.mp4

: Observations of "leader cells" responding to GLI2 inhibition. : Injured epithelial cells release Sonic Hedgehog (SHH)

Based on the full text of the study, supplemental videos (often named with similar codes) typically demonstrate: g9048.mp4

: The resulting stiffened tissue triggers non-canonical activation of the transcription factor GLI2 in epithelial cells.

: This "chemo-mechanical" loop promotes cell proliferation, migration, and the transition of normal cells into invasive cancer cells. Potential Video Content

: Time-lapse footage of cancer cells moving across substrates of varying stiffness.