The "Inclu ALL DLC" portion of your query refers to the six official expansions. Reviewers generally consider this the definitive way to play, though it has mixed highlights.
: This patch was major for Xbox players, delivering 4K support , enhanced god-ray effects, and increased draw distances for trees, grass, and NPCs. Fallout.4.v1.10.50.0.Hotfix.Inclu.ALL.DLC.part2...
: While it intended to improve stability, some PC users reported that this version could cause crashes at launch or break the Fallout 4 Script Extender (F4SE), necessitating an F4SE update or a roll-back to version 1.10.40. Content Review: "ALL DLC" & GOTY Status The "Inclu ALL DLC" portion of your query