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Mechanisms of Synaptic Strength and Spine Size Regulation Reference: eLife 2023;12:e91566 1. Overview

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Dendritic spines are tiny protrusions on neurons that receive input from other cells. Their size is a direct physical indicator of —larger spines generally correlate with stronger connections. This report examines how these structures change size (structural plasticity), which is a fundamental process underlying learning and memory. 2. Key Findings Mechanisms of Synaptic Strength and Spine Size Regulation