One of the most heartbreaking departures, she died in the Season 8 plane crash.

Though he survived the initial plane crash, he succumbed to his injuries in the Season 9 premiere.

He resigned from the hospital to run the Catherine Fox Foundation in Boston.

How many did you get right? If you want to dive deeper into specific seasons or character arcs, hit you the hardest?

Test your knowledge on these iconic characters as of the end of 2022: April Kepner Lexie Grey Arizona Robbins Heather Brooks Tom Koracick Mark Sloan Jackson Avery Answer Key & Status Check